The 1980 Nevada Wolf Pack football team represented the University of Nevada, Reno as a member of the Big Sky Conference during the 1980 NCAA Division I-AA football season.
Led by fifth-year head coach Chris Ault, the Wolf Pack compiled an overall record of 6–4–1 with a mark of 4–3 in conference play, tying for second place in the Big Sky.
The team played home games at Mackay Stadium in Reno, Nevada.