Evonne Goolagong Cawley defeated Chris Evert Lloyd in the final, 6–1, 7–6(7–4) to win the ladies' singles tennis title at the 1980 Wimbledon Championships.

The second-set tiebreak was the first played in the ladies singles final at Wimbledon, and the match was the first singles final (men's or women's) to end on a tiebreak.

Goolagong Cawley was the first Wimbledon champion to defeat four top-ten ranked players en route to victory.

[2] Martina Navratilova was the two-time defending champion, but lost to Evert Lloyd in the semifinals in a rematch of the previous two year's finals.

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