The 1981 Avon Championships of Houston was a women's tennis tournament played on indoor carpet courts at the Summit in Houston, Texas in the United States that was part of the 1981 Avon Championships Circuit.

It was the 11th edition of the tournament and was held from February 16 through February 22, 1981.

[1] Second-seeded Hana Mandlíková won the singles title and earned $22,000 first-prize money.

First-seeded Tracy Austin withdrew due to a back injury.

[1][2] Hana Mandlíková defeated Bettina Bunge 6–4, 6–4 Sue Barker / Ann Kiyomura defeated Regina Maršíková / Mary Lou Piatek 5–7, 6–4, 6–3