1981 NCAA Division I baseball tournament

Eight regional competitions were held to determine the participants in the final event.

Seven regions held a four team, double-elimination tournament while one region included six teams, resulting in 34 teams participating in the tournament at the conclusion of their regular season, and in some cases, after a conference tournament.

[1] The thirty-fifth tournament's champion was Arizona State coached by Jim Brock.

The Most Outstanding Player was Stan Holmes of Arizona State.

[2] The winners of each Regional advanced to the College World Series.