The 1981 Pepsi Grand Slam was a men's tennis tournament played on outdoor clay courts at the Boca West Country Club in Boca Raton, Florida, United States.

It was a special event, not part of the 1980 Volvo Grand Prix circuit but the title is recognized by the Association of Tennis Professionals (ATP).

Four–time winner and defending champion Björn Borg withdrew a day before the tournament began after coming down with the flu.

[2] John McEnroe won the singles title and $150,000 first prize money.

[3][4] This tournament was televised by CBS Sports immediately following their telecast of the 1981 Daytona 500 held some 220 miles further north up Florida's coast in Daytona Beach, Florida.