The 65th running of the Tour of Flanders cycling classic was held on Sunday, 5 April 1981.

Dutch rider Hennie Kuiper claimed a solo victory ahead of his fellow Dutchmen Frits Pirard and Jan Raas.

[1][2] 45 of 184 riders finished.

[3] The race started in Sint Niklaas and finished in Meerbeke (Ninove) – covering 267 km.

This Tour of Flanders race article is a stub.