Tenth was the Coloni of Pierre-Henri Raphanel, just ahead of the two Zakspeeds of Aguri Suzuki and Bernd Schneider, the Japanese driver outpacing his more experienced team-mate.
After their defeat in Brazil, McLaren spent eight days testing at Imola prior to the San Marino Grand Prix.
Riccardo Patrese showed his and Williams' revival with fourth on the grid followed by Gerhard Berger (Ferrari) with Thierry Boutsen rounding out the top six.
Mansell fell off a little after that and found himself battling with Riccardo Patrese while on the second lap Ivan Capelli had a nasty accident in his March.
On lap four, fifth-placed Gerhard Berger's Ferrari speared off the track at the fast Tamburello corner due to a mechanical failure.
The McLarens proceeded to pull away from the competition while behind them there was more drama as Stefano Modena put his Brabham into the wall rather violently, escaping unhurt.
Thierry Boutsen and Alex Caffi were initially disqualified after a protest from Ligier because they had changed tyres in the pitlane before the second start, but were reinstated following an appeal.
The Prost/Senna war began to build up speed after the Frenchman said that McLaren had a pre-race agreement that whoever led into the first turn should stay there, which was ironically suggested by Senna.