Running back Eric Dickerson held out of training camp, during a contract dispute.
The Colts were embarrassed at home in week two by the putrid Patriots, losing 16–14 for New England's lone win of 1990.
Trailing 25–14 in the 4th quarter, rookie quarterback Jeff George led an improbable and spectacular comeback which included two touchdowns to tie the game with little time left.
The Colts then intercepted Mark Rypien and returned the ball for the go-ahead touchdown.
The Colts pulled off the upset in dramatic fashion with one of George's most memorable games of his career.