On November 11, 1990, Marcus Dupree made his NFL debut against the New York Giants.

The Rams, temporarily playing in the Los Angeles Memorial Coliseum, looked to improve on their 11–5 season from 1989 and make the playoffs for the third consecutive season and be possible contenders for the Super Bowl.

However, the Rams would struggle all season, starting 1–4 before winning two of their next three games before losing their next two as they dipped to a 3–7 record.

After a win over Cleveland, the Rams upset the 49ers 28–17 in San Francisco to improve to 5–7.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams 46 active, 4 inactive, 5 practice squad Reserve