The team with the most points at the end of the season crowned champions.
APOP Paphos and APEP were relegated from previous season and played in the 1991–92 Cypriot Second Division.
They were replaced by the first two teams of the 1990–91 Cypriot Second Division, Evagoras Paphos and Omonia Aradippou.
The 12th-placed team Olympiakos faced the 3rd-placed team of the 1991–92 Cypriot Second Division APEP, in a two-legged play-off for one spot in the 1992–93 Cypriot First Division.
Olympiakos won both matches and secured their place in the 1992–93 Cypriot First Division.