The 1991 NCAA Division III women's basketball tournament was the tenth annual tournament hosted by the NCAA to determine the national champion of Division III women's collegiate basketball in the United States.

[1] St. Thomas (MN) defeated Muskingum in the championship game, 73–55, to claim the Tommies' first Division III national title.

The championship rounds were hosted by the University of St. Thomas in Saint Paul, Minnesota.

There was a slight adjustment to the tournament's format in 1991, even though the field size remained fixed at 32 teams.

Under the new format, the four sectional champions advanced to the national semifinal, or Final Four, round.