The 1991 NCAA Division II women's basketball tournament was the tenth annual tournament hosted by the NCAA to determine the national champion of Division II women's collegiate basketball in the United States.

[1] North Dakota State defeated Southeast Missouri State in the championship game, 81–74, claiming the Bison's first NCAA Division II national title.

The championship rounds were contested at the Show Me Center at Southeast Missouri State University in Cape Girardeau, Missouri.

Location: Sports Center Host: University of Pittsburgh at Johnstown Location: Joseph G. Echols Memorial Hall Host: Norfolk State University Location: Warrior Gym Host: California State University, Stanislaus Location: Show Me Center Host: Southeast Missouri State University Location: Hyslop Sports Center Host: University of North Dakota Location: Regents Hall Host: Northern Kentucky University Location: Pete Mathews Coliseum Host: Jacksonville State University Location: Dana Center Host: Bentley College Final Four Location: Show Me Center Host: Southeast Missouri State University