Incumbent Republican Congressman Mark Sanford of the 1st congressional district, in office since 1995, defeated Natural Law candidate Joseph F. Innella.

Incumbent Republican Congressman Floyd Spence of the 2nd congressional district, in office since 1971, defeated Natural Law candidate Maurice T. Raiford.

Incumbent Republican Congressman Lindsey Graham of the 3rd congressional district, in office since 1995, defeated Democratic challenger Debbie Dorn.

Incumbent Republican Congresswoman Bob Inglis of the 4th congressional district, in office since 1993, defeated Democratic challenger Darrell E. Curry.

Incumbent Democratic Congressman John M. Spratt, Jr. of the 5th congressional district, in office since 1983, defeated Republican challenger Larry Bigham.