The 1998 Nicholls State Colonels football team represented Nicholls State University as a member of the Southland Football League during the 1998 NCAA Division I-AA football season.
Led by Darren Barbier in his fourth and final season as head coach, the Colonels compiled an overall record of 4–7 with a mark of 3–4 in conference play, placing fifth in the Southland.
Nicholls State played home games at John L. Guidry Stadium in Thibodaux, Louisiana.
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