The 1999–2000 Nemzeti Bajnokság I is the 49th season of the Nemzeti Bajnokság I, Hungary's premier Handball league.
The following 12 clubs compete in the NB I during the 1999–2000 season: Pld - Played; W - Won; D - Drawn; L - Lost; GF - Goals for; GA - Goals against; Diff - Difference; Pts - Points.
1 Dunaferr SE entered 2000-01 Cup Winners' Cup as winners of 1999–2000 Magyar Kupa.
Herz-FTCNinth title Mónika Bárdos, Nikolett Brigovácz, Julianna Cioculeas, Rita Deli, Erika Kirsner, Beatrix Kökény, Veronika Kovács, Dóra Lőwy, Ildikó Pádár, Zsófia Pászor, Eszter Siti, Tímea Sugár, Enikő Tóth and Alexandra Wolf.Head coach: András Németh.