The 2021–22 Nemzeti Bajnokság I (known as the K&H női kézilabda liga for sponsorship reasons) was the 71st season of the Nemzeti Bajnokság I, Hungarian premier Handball league.

After the 2020–21 season, Békéscsabai Előre NKSE and Boglári Akadémia-SZISE were relegated to the 2021–22 Nemzeti Bajnokság I/B.

They were replaced by two clubs from the 2020–21 Nemzeti Bajnokság I/B; Moyra-Budaörs Handball and Vasas SC.

Following is the list of clubs competing in 2021–22 Nemzeti Bajnokság I, with their president, head coach, kit manufacturer and shirt sponsor.

Attendance numbers without playoff matches.