Purdue defeated Duke 62-45 in Carolyn Peck's final game as head coach for the Boilermakers.

She had previously announced her intention of leaving Purdue after two seasons to coach the expansion WNBA Orlando Miracle.

Duke's Georgia Schweitzer tied her career high with 22 points, and the Blue Devils advanced to the Final Four for the first time in their history.

[2][3] Connecticut was the 1 seed in the Mideast regional, and hosted the first two rounds at their home court, Gampel Pavilion.

Xavier led by as many as ten points in the second half, and with just over two minutes to play, the Musketeers had an eight-point lead, 84–76.

With 37 seconds left in the game Xavier's Nikki Kremer was fouled, and headed to the line, having hit all eight free throw attempts on the day.

After Shea Ralph missed a jumper, Tamika Williams snared the rebound and was fouled.

Xavier tried two desperation shots, but missed both, and UConn narrowly escaped an upset on their own court.

Georgia hit nine of their sixteen three-point attempts, and held the Miller twins, who had been averaging 37 points per game, to only 31.

[8] Data source[1] * – Denotes overtime period E-East; ME-Mideast; MW-Midwest; W-West.