The 1999 Spanish motorcycle Grand Prix was the third round of the 1999 Grand Prix motorcycle racing season.

It took place on 9 May 1999 at the Circuito Permanente de Jerez.

The event is notable for being the last round that 5-time 500cc and reigning World Champion Mick Doohan participated in.

Doohan did not start the race due to crashing in the wet qualifying session, resulting in career-ending leg injuries.

Below are the standings for the top five riders and constructors after round three has concluded.