The 1999 US Open was a tennis tournament played on outdoor hard courts at the USTA National Tennis Center in New York City in New York in the United States.

It was the 119th edition of the US Open and was held from August 30 through September 12, 1999.

Andre Agassi defeated Todd Martin, 6–4, 6–7(5–7), 6–7(2–7), 6–3, 6–2 Serena Williams defeated Martina Hingis, 6–3, 7–6(7–4) Sébastien Lareau / Alex O'Brien defeated Mahesh Bhupathi / Leander Paes, 7–6(9–7), 6–4 Serena Williams / Venus Williams defeated Chanda Rubin / Sandrine Testud, 4–6, 6–1, 6–4 Ai Sugiyama / Mahesh Bhupathi defeated Kimberly Po / Donald Johnson, 6–4, 6–4 Jarkko Nieminen defeated Kristian Pless 6–7, 6–3, 6–4 Lina Krasnoroutskaya defeated Nadia Petrova 6–3, 6–2 Julien Benneteau / Nicolas Mahut defeated Tres Davis / Alberto Francis 6–4, 3–6, 6–1 Dája Bedáňová / Iroda Tulyaganova defeated Galina Fokina / Lina Krasnoroutskaya 6–3, 6–4

Withdrawals: Steffi Graf,[1] Anna Kournikova[2]