It participated in the Balkan Wars, initially as part of the 6th Infantry Division, fighting in the battles of Sarantaporos, Giannitsa, Bizani (where it played a distinguished role under Major Ioannis Velissariou), Kilkis–Lachanas and Kresna–Djumaya (where the regiment lost almost half its strength and all three of its battalion commanders).

The unit was disbanded and most of its officers were imprisoned until August, when, after the exile of King Constantine I and the assumption of the government by Venizelos, Greece formally entered World War I on the side of the Entente.

[1] The 1/38 Regiment was re-formed at Larissa as part of the 1st Infantry Division, and participated in the Macedonian front operations in 1918, recapturing the city of Serres.

In December 1975, the 121st Special Covering Regiment (121 ΕΣΠ) at Ano Kalamonas in Rhodes, was renamed into the 38th Hellenic Gendarmerie Command (38η Διοίκηση Ταγμάτων Ελληνικής Χωροφυλακής, 38 ΔΤΕΧ), reviving the traditions of the 1/38.

This connection was further emphasized in September 2000, when the unit received its current name, 1/38 National Guard Command "Bizani" (1/38 Διοίκηση Ταγμάτων Εθνοφυλακής «ΜΠΙΖΑΝΙ»).