2-Oleoylglycerol (2OG) is a monoacylglycerol that is found in biologic tissues.

Its synthesis is derived from diacylglycerol precursors.

It is metabolized to oleic acid and glycerol primarily by the enzyme monoacylglycerol lipase (MAGL).

[2] 2OG has been shown to increase glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels following administration to the small intestine.

[2] 2OG has also been discovered to potentiate G protein and not β-arrestin signaling via allosteric binding of the 5-HT2A receptor.