The 2000–01 Oklahoma Sooners men's basketball team represented the University of Oklahoma in competitive college basketball during the 2000–01 NCAA Division I men's basketball season.

The Oklahoma Sooners men's basketball team played its home games in the Lloyd Noble Center and was a member of the National Collegiate Athletic Association's Big 12 Conference.

The team posted a 26–7 overall record (12–4 Big 12).

The Sooners received a bid to the 2001 NCAA tournament as No.

13 seed Indiana State in the opening round, 70–68 in overtime.