The 2020–21 Oklahoma Sooners basketball team represented the University of Oklahoma in the 2020–21 NCAA Division I men's basketball season.

They were led by 10th-year head coach Lon Kruger and played their home games at the Lloyd Noble Center in Norman, Oklahoma, as members of the Big 12 Conference.

7 seed in the Big 12 tournament, they defeated Iowa State before losing to Kansas in the quarterfinals.

They received an at-large bid to the NCAA tournament as the No.

All postseason tournaments were canceled due to the ongoing COVID-19 pandemic.