The 2000–01 Wake Forest Demon Deacons men's basketball team represented Wake Forest University as a member of the Atlantic Coast Conference during the 2000–01 NCAA Division I men's basketball season.

Led by head coach Dave Odom, the team played their home games at Lawrence Joel Veterans Memorial Coliseum in Winston-Salem, North Carolina.

The Demon Deacons finished tied for fifth in the ACC regular season standings.

Wake Forest received an at-large bid to the NCAA tournament as the No.

10 seed Butler in the opening round,[2] to end the season with a record of 19–11 (8–8 ACC).