The season began with non-conference play on Saturday, August 26, 2000.
At the conclusion of the regular season, Kansas State won the North Division championship with a 11–3 (6–2) record.
Oklahoma finished atop the South Division standings, with a perfect regular season 11–0 (8–0).
[1] With the win, the Sooners advance to the BCS National Championship Game.
Oklahoma won the BCS National Championship Game at the 2001 Orange Bowl, defeating Florida State, 13–2, in Miami Gardens.