The Sooners opened the season ranked #19,[1] the first time they had made it into a pre-season poll in five years.

Beginning at the end of September, OU defeated #11 Texas (63–14), #2 Kansas State (41–31), and #1 Nebraska (31–14).

The Sooners finished the season 13-0, claiming Oklahoma's seventh national championship in football and first since 1985.

Three OU players were named consensus All Americans after the 2000 season: linebacker Rocky Calmus, quarterback Josh Heupel, and free safety J. T. Thatcher.

The 2001 NFL draft was held on April 21–22, 2001 at the Theatre at Madison Square Garden in New York City.