Amateur club Uruguay SC narrowly missed a major second-round upset, losing in overtime to the Tampa Bay Mutiny.
Mid Michigan came closest to duplicating its second-round upset, losing in a shootout to eventual runner-up Miami.
Two referees were used for all games from the second round through the semifinals as part of a FIFA experiment.
Home teams listed on top of bracket Note: Scorelines use the standard U.S. convention of placing the home team on the right-hand side of box scores.
Twelve MLS, nine A-League, seven D3 Pro League teams enter.