Outgoing Republican Representative Tom Coburn was replaced by Democrat Brad Carson, who won 54.9% of the vote.

Incumbent Republican Wes Watkins won election to a 13th term in office with 86.6% of the vote.

Incumbent Republican J.C. Watts won reelection with 64.9% of the vote, securing a fourth term in office.

Incumbent Republican Ernest Istook won reelection with 68.4% of the vote, securing a fifth term in office.

Incumbent Republican Frank Lucas won reelection with 59.3% of the vote, winning a fourth term in office.