Senator Bill Frist won re-election to a second term, defeating Democratic candidate Jeff Clark.

Bill Frist vastly overperformed George W. Bush in the concurrent presidential election by 13.95%.

Senator was unopposed in the Republican primary.

[2] The Democratic primary was held on August 3, 2000.

In a field of five candidates, Jeff Clark, a professor at Middle Tennessee State University, edged out John Jay Hooker to win the nomination.