The year 2000 was the 8th year in the history of the Ultimate Fighting Championship (UFC), a mixed martial arts promotion based in the United States.

In 2000 the UFC held 6 events beginning with, UFC 24: First Defense.

The following fighters fought their first UFC fight in 2000:

UFC 27 was an event held in New Orleans, Louisiana, on September 22, 2000, and the last event held by the UFC before its adoption of the new "Unified Rules of Mixed Martial Arts".