The Copa Mercosur 2001 was the 4th and last season of the Copa Mercosur, CONMEBOL's club tournament.

The competition started on 21 July 2001 and concluded on 24 January 2002 with San Lorenzo beating Flamengo in the final.

San Lorenzo won 6–3 on aggregate.

San Lorenzo won 5–3 on aggregate.

2–2 on aggregate, Flamengo won 4–2 on penalties Originally scheduled for Dec 19 but postponed to January 24, 2002 due to social unrest in Argentina 1–1 on aggregate, San Lorenzo won 4–3 on penalties