The 2001 Ole Miss Rebels football team represented the University of Mississippi as a member of the Western Division of the Southeastern Conference (SEC) during the 2001 NCAA Division I-A football season.
Led by third-year head coach David Cutcliffe, the Rebels compiled an overall record of 7–4 with a mark of 4–4 in conference play, placing in a three-way tie for third in the SEC's Western Division.
Ole Miss played home games at Vaught–Hemingway Stadium in Oxford, Mississippi.
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