[4] Week 3 was Mark Brunell's last game as a Jaguar, as he was benched forcing rookie quarterback Byron Leftwich to take his spot for the rest of the season.

Jacksonville defeated New Orleans 20–19 in the week 16 game despite the River City Relay, a play that has gone down in NFL lore.

During free agency, the Jaguars signed former Philadelphia Eagles defensive end Hugh Douglas and former Indianapolis Colts linebacker Mike Peterson.

A standout moment from the game occurred when Colts' rookie DB Mike Doss caused a fumble by Jaguars' RB Fred Taylor.

The Jaguars then moved deep into Colts' territory, but a fumbled field goal snap by punter/holder Mark Royals thwarted their efforts.

After the Colts went three–and–out and a strong punt return set Jacksonville up at the Indianapolis 31–yard line, Fred Taylor made a 32–yard run, evading Mike Doss as he fell, to score a touchdown and put the Jaguars ahead with just a minute remaining.

Manning's attempt to respond ended in an interception, sealing the Jaguars' first–ever victory over the Colts in a surprising upset.