Departures: Running Back Trung Canidate was traded to the Washington Redskins for guard David Loverne.
Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Kurt Warner was given one more shot as starter for the Rams and passed for 353 yards and one touchdown to Torry Holt.
The Giants, still smarting from their chaotic playoff loss to the 49ers the previous season, bullied the Rams by recovering the three fumbles and wracking up 146 rushing yards by Tiki Barber en route to a 23–13 win.
Warner was briefly hospitalized with a concussion and Rams coach Mike Martz would start Marc Bulger at QB for the remainder of the season.
The Rams and Niners squared off in a tight contest where the game lead tied or changed seven times.
Tai Streets and Torry Holt traded touchdown catches in the first quarter, and after a Jeff Chandler field goal put the Niners up 10–7 at the half the game kicked up a gear as Marshall Faulk and Kevan Barlow traded rushing scores in the third, then after two Marc Bulger drives produced ten Rams points and a 24–17 lead Jeff Garcia drove the Niners down field and Terrell Owens' 13-yard catch with 19 seconds to go forced overtime.
With Michael Vick sidelined with injury, the Falcons' season was essentially over at 1–4 entering the game, and the Rams merely added more punishment; they downed T. J. Duckett in the Falcons endzone for a safety and put up 496 yards of offense and 36 points in a 36–0 shutout; the last touchdown came when Travis Fisher picked off Kurt Kittner and ran back a 74-yard touchdown.
In a rematch of Super Bowl XIV the Rams faced their former backup quarterback Tommy Maddox.
Tim Rattay unloaded three touchdowns to Brandon Lloyd, Terrell Owens, and Tai Streets while Bulger was sacked five times and picked off twice.
Bulger was then strip-sacked by Ronald McKinnon and the subsequent Neil Rackers field goal put the Cardinals up 27–24.
But Bulger completed a key fourth-down throw and Jeff Wilkins drilled a 24-yarder as time expired.
Marc Bulger threw for 222 yards but the longest pass play came when Isaac Bruce completed a 41-yarder to Dane Looker in the third quarter.
The 4–8 Browns fell to 4–9 after two interceptions (one a pick-six by Aeneas Williams) and two fumbles aided the Rams to a 26–20 win.
The Rams for their part picked off Jon Kitna three times and Marshall Faulk had his highest rushing game of the year (121 yards and a score).