The draft was held from April 24–25, 2004, at the Theater at Madison Square Garden in New York City.
Due to his refusal to play for the Chargers, Manning was later traded to the New York Giants for the fourth overall pick Philip Rivers of NC State.
The University of Miami set an NFL record for the most first rounders drafted with six, which would be tied by Alabama in 2021.
Ohio State set an NFL draft record having 14 total players selected through all rounds.
It was the first draft to have produced two quarterbacks who each won multiple Super Bowls, with Ben Roethlisberger winning his second in 2008 and Eli Manning his second in 2011.