2005–06 Croatian First League was the 16th season of the Croatian handball league since its independence and the fifth season of the First League format.
Intermediate results from the first part are transferred, and the clubs play two more games with teams from the same group and four with teams from the second group of the first part of the championship (16 in total, in the table of 20 matches).
[1] Play-offs to stay in the First league or to be demoted to the Second League for teams from 7 to 16 place.