The 2005–06 Virginia Tech Hokies men's basketball team represented Virginia Polytechnic Institute and State University during the 2005–06 NCAA Division I men's basketball season.

The Hokies were led by third-year head coach Seth Greenberg and played their home games at Cassell Coliseum in Blacksburg, Virginia as second-year members of the Atlantic Coast Conference.

10 seed in the ACC tournament, they were defeated in the first round by Virginia 56–60.

They were defeated 54–73 by Georgia Tech in the quarterfinals of the ACC tournament.

They were invited to the National Invitation Tournament where they defeated Temple in the first round to advance to the second round where they lost to Memphis.