The team played its home games at the Kohl Center in Madison, Wisconsin as a member of the Big Ten Conference.

This Wisconsin team was off to a very promising and exciting start to the season, beginning 14–2, and 4–0 in Big-Ten play.

The beginning of the end came in the 17th game of the season with a loss at Ohio State on January 18, 2006.

This marked the first game Wisconsin played without freshman Marcus Landry and sophomore Greg Stiemsma, who were each ruled academically ineligible for the second semester.

Then the next game, Wisconsin had their 27-game home non-conference winning streak snapped in a shocking upset, as North Dakota State won, 62–55, at the Kohl Center.