The 2005 Big South Conference men's basketball tournament took place March 1–5, 2005, at campus sites.
The tournament was won by the Winthrop Eagles, their first of what would become four consecutive titles, led by head coach Gregg Marshall.
They defeated the #7 Charleston Southern Buccaneers in the championship game 68–46.
All games were hosted at campus sites, with home-field advantage going to the higher seed.
This gave the #1 seed Winthrop home-court advantage throughout the tournament.