The 2005 Ole Miss Rebels football team represented the University of Mississippi as a member of the Western Division of the Southeastern Conference (SEC) during the 2005 NCAA Division I-AA football season.
Led by first-year head coach Ed Orgeron, the Rebels compiled an overall record of 3–8 with a mark of 1–7 in conference play, tying of fifth place in the SEC's Western Division.
Ole Miss played home games at Vaught–Hemingway Stadium in Oxford, Mississippi.