The 2005 Regions Morgan Keegan Championships and the Cellular South Cup were tennis tournaments played on indoor hard courts.

It was the 30th edition of the Regions Morgan Keegan Championships, the 20th edition of the Cellular South Cup, and was part of the International Series Gold of the 2005 ATP Tour, and of the Tier III Series of the 2005 WTA Tour.

Both the men's and the women's events took place at the Racquet Club of Memphis in Memphis, Tennessee, United States, from February 14 through February 20, 2005.

Kenneth Carlsen defeated Max Mirnyi, 7–5, 7–5[1] Vera Zvonareva defeated Meghann Shaughnessy, 7–6(7–3), 6–2[2] Simon Aspelin / Todd Perrey defeated Bob Bryan / Mike Bryan, 6–4, 6–4 Miho Saeki / Yuka Yoshida defeated Laura Granville / Abigail Spears 6–3, 6–4