[3][2][note 1] The 49ers 3,587 total offensive yards were the fewest of any team in 2005, and their 239 points scored were third-worst in the NFL.
Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve In Mike Nolan's debut as head coach, the 49ers beat divisional rival St. Louis Rams.
The Rams were poised to score again, but Michael Adams intercepted Marc Bulger with 52 seconds left to seal the victory and start the season with a win.
The 49ers were handily beaten by the Philadelphia Eagles as Donovan McNabb threw five touchdown passes, four of which were in the first 19 minutes of the game.
Rookie quarterback Alex Smith made his regular season debut, playing the final possession and throwing one incomplete pass.
A game played in Mexico City at Azteca Stadium garnered the largest crowd in regular season history, with 103,467 fans in attendance.
The Cardinals then began to dominate, scoring 31 consecutive points, including six field goals by Neil Rackers.
San Francisco could do nothing right, with Alex Smith getting sacked five times, losing a fumble, and throwing an interception.
On the other side of the ball, the Redskins quarterback Mark Brunell tossed three touchdowns and Clinton Portis rushed for three more, rolling up 448 total yards.
For the second straight game, the 49ers failed to score a touchdown, this time managing only two field goals in the loss.
However, the game turned in the Bears' favor when Nathan Vasher ran back an attempted field goal 108 yards for a touchdown.
The game was not as close as the final score suggested, as the Titans forced four turnovers and Steve McNair threw for 343 yards and three touchdowns.
In their fifth loss in as many games (the 49ers' second five-game losing streak), the 49ers fell to the division rival Cardinals.
With the victory, the Seahawks completed the division perfectly, 6–0, and gained a two-game lead for home-field advantage throughout the playoffs.
The 49ers broke their seven-game losing streak with a big performance from their running backs, Maurice Hicks and Frank Gore, who combined for 177 yards and 3 touchdowns.
The game was only decided in the final minute when Ben Emanuel intercepted a pass at the San Francisco 19-yard line.