Their 6–42 record between 2007 and 2009 was the worst for such a period by any team between the World War II Chicago Cardinals and the 2015 to 2017 Cleveland Browns.
On October 10, news broke out that head coach Mike Martz announced he was leaving the team indefinitely after being diagnosed with a bacterial infection.
Though Martz was medically cleared to return, management refused to let him do so and he was fired the day after the final regular season game.
As second-year running back Steven Jackson earned the starting position, this year was the final season for future Hall of Famer Marshall Faulk as he missed the following season because of reconstructive knee surgery, which ultimately led to his retirement in 2007.
Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.