The Primera División Uruguaya 2005 started on 5 March 2005 and ended on 12 July 2005.
The league was a single round-robin tournament and not relegation and promotion from Segunda División Uruguay.
But along with Apertura 2005 of 2005–06 season, the whole schedule of 2005 would count in a final table, the bottom three would direct relegated.
Defensor Sporting refused to play the tiebreaker match due to Nacional winning their last match by a contested penalty in 7th minute of injury time.
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