The 2006–07 Macedonian Second Football League was the fifteenth season since its establishment.
The first 22 matchdays will consist of a regular double round-robin schedule.
The league standings at this point will then be used to determine the games for the last 11 matchdays.
Note: After the play-off chaos, the Football Federation of Macedonia was decided that no teams were relegated from the Second League and the all 5 winners from the Third League were promoted.
In addition, the FFM was decided will be played an additional play-off match between the two second placed team from the Northern group of the Third League, Lokomotiva and the second placed from the Southwestern group Korabi and the winner Lokomotiva was promoted to the Second League.