The 2005–06 Macedonian Second Football League was the fourteenth season since its establishment.
It began on 6 August 2005 and ended on 20 May 2006.
[1] Every team will play three times against each other team for a total of 33 matches.
The first 22 matchdays will consist of a regular double round-robin schedule.
The league standings at this point will then be used to determine the games for the last 11 matchdays.