New teams to the league included Albi and Montauban who were promoted from 2004–05 Pro D2, replacing relegated sides Toulon and Pau.

Toulouse and Clermont each entered the final week with a chance to top the ladder, but Stade Français' win over Agen (without a bonus point) made it impossible for Clermont to overtake them, while Toulouse failed to secure the bonus point in their win over Bourgoin that would have made it possible for them to pip the Parisians for the top seed.

The final Heineken Cup berth came down to the last round as well, with Bourgoin holding off the challenge of Top 14 newcomers Montauban.

In the end, Agen, who were next-to-last entering the final week, were consigned to the drop by league leaders Stade Français.

However, the quarterfinal losses of Biarritz and Stade Français, the last two remaining French sides in the 2006–07 Heineken Cup, to English sides Northampton Saints and Leicester Tigers, meant that the "extra" Heineken Cup place would go to England.