The 2006 Acura Classic was a women's tennis tournament played on outdoor hard courts at the La Costa Resort and Spa in San Diego, California, United States, which was part of Tier I of the 2006 WTA Tour.

It was the 28th edition of the tournament and was held from July 29 through August 6, 2006.

Second-seeded Maria Sharapova won the singles title and earned $196,900 first-prize money as well as 300 ranking points.

Maria Sharapova defeated Kim Clijsters, 7–5, 7–5 Cara Black / Rennae Stubbs defeated Anna-Lena Grönefeld / Meghann Shaughnessy, 6–2, 6–2