The 2006 Conference USA men's basketball tournament was held March 8–11 at the FedExForum in Memphis, Tennessee.
The Tigers, in turn, received an automatic bid to the 2006 NCAA tournament.
They were joined in the tournament by fellow C-USA member UAB, who earned an at-large bid.
Eight teams, Charlotte (Atlantic 10), Cincinnati (Big East), DePaul (Big East), Louisville (Big East), Marquette (Big East), Saint Louis (Atlantic 10), South Florida (Big East), and TCU (Mountain West), departed the conference, while six new teams were added, Marshall (MAC), Rice (WAC), SMU (WAC), Tulsa (WAC), UCF (Sun Belt), and UTEP (WAC).
All remaining tournament seeds were determined by regular season conference records.