The 2006 Copa Toyota Libertadores was the 47th edition of the Copa Libertadores, CONMEBOL's annual football club tournament.

38 teams from 11 football associations took part, starting with the first qualifying round played on 24 January 2006.

Internacional won this edition for their first title, beating São Paulo 4–3 on aggregate.

6 winners from the qualifying round and the 26 pre-qualified clubs are drawn into 8 groups of 4 teams each.

The top 2 teams in each group will advance to the Libertadores Cup play-offs.